Publications

Our most recent papers are highlighted in red. Links for each paper are generally to Entrez-Pubmed. Please email me for reprint requests. Word images were created using Wordle.

For a more informal take on science, check out my other writing.

Structural Virology: Protein-RNA Interactions (1999-date)

Curry, S., Kotik-Kogan, O., Conte, M.R. and Brick, P. Getting to the end of RNA: structural analysis of protein recognition of 5′ and 3′ termini Biochim. Biophys. Acta 1789, 653-666 (2009) Abstract | Open Access Reprint

Garnett, J.A., Liu, Y., Leon, E., Allman, S., Friedrich, N., Saouros, S. Curry, S., Soldati-Favre, S. Davis, B., Feizi, T. and Matthews, S. Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) of Toxoplasma gondii. Prot. Sci. 18, 1935-1947 (2009) Abstract

Kafasla, P., Morgner N., Pöyry, T.A.A., Curry, S., Robinson, C.V. & Jackson, R.J. Polypyrimidine tract binding protein stabilises the encephalomyocarditis virus IRES structure via binding multiple sites in a unique orientation Mol. Cell 34, 556-568 (2009) Abstract

Kotik-Kogan, O., Valentine, E.R., Sanfelice, D., Conte, M.R. & Curry, S. Structural analysis reveals conformational plasticity in the recognition of RNA 3′-ends by the human La protein Structure 16, 852-862 (2008) Abstract

Sanfelice, D., Kelly, G., Curry, S. & Conte, M.R. NMR assignment of the N-terminal region of human La free and in complex with RNA targets Biomolec. NMR Assignments 2, 107-109 (2008) Abstract

Monie, T.P., Perrin, A.J., Birtley, J.R., Sweeney, T.R., Karakasiliotis, I., Chaudry, Y., Roberts, L.O., Matthews, S., Goodfellow, I.G. & Curry, S. Structural insights into the transcriptional and translational roles of Ebp1 EMBO J. 26, 3936-3944 (2007) Abstract

Rideau, A.P., Gooding, C., Simpson, P.J., Monie, T.P., Lorenz, M., Hüttelmaier, S., Singer, R.H., Matthews, S., Curry, S. & Smith, C.W.J. A peptide motif in Raver1 mediates splicing repression by interaction with the PTB RRM2 domain Nature Struct. Molec. Biol. 13, 839-848 (2006) Abstract

Petoukhov, M.V., Monie, T.P., Allain, F.H.-T., Matthews, S., Curry, S. & Svergun, D.I. Conformation of polypyrimidine tract binding protein in solution. Structure 14, 1021-1027 (2006) Abstract

Curry, S. & Conte, M.R. A terminal affair: 3'-end recognition by the human La protein TIBS 31, 303-305 (2006) Abstract

Monie, T.P., Hernandez, H., Robinson, C.V., Simpson, P.J., Matthews, S. & Curry, S. The polypyrimidine tract binding protein is a monomer. RNA 11, 1803-1808 (2005) Abstract

Simpson, P.J., Monie, T.P., Szendröi, A., Davydova, N., Tyzack, J.K., Conte, M.R., Read, C.M., Cary, P.D., Svergun, D.I., Konarev, P.V., Curry, S. & Matthews, S. Structure and RNA interactions of the N-terminal RRM domains of PTB. Structure 12, 1631-1643 (2004) Abstract

Alfano, C., Sanfelice, D., Babon, J., Kelly, G. Curry, S. & Conte, M.R. Structural analysis of co-operative RNA binding by the La motif and central RRM domain of human La protein. Nature Struct. Molec. Biol. 11, 323-329 (2004) Abstract | News & Views

Sanfelice, D., Babon, J., Kelly, G. Curry, S. & Conte, M.R. Resonance assignment and secondary structure of the La motif. J. Biomol. NMR 29, 449-450 (2004) pdf

Alfano, C., Babon, J., Kelly, G. Curry, S. & Conte, M.R. Resonance assignment and secondary structure of an N-terminal fragment of the human La protein. J. Biomol. NMR 27, 93-94 (2003) pdf

Fleming, K., Ghuman, J. Yuan, Y., Simpson, P., Szendröi, A., Matthews, S. & Curry, S. Solution Structure and RNA Interactions of the RNA Recognition Motif from Eukaryotic Translation Initiation Factor 4B. Biochemistry 42, 8966-8975 (2003) Abstract

Jacks, A., Babon, J., Kelly, G., Manolaridis, I., Cary, P.D., Curry, S. & Conte, M.R. Structure of the C-terminal domain of human La protein reveals a novel RNA recognition motif coupled to a helical nuclear retention element. Structure 11, 833-843 (2003) Abstract

Yuan, X., Davydova, N., Conte, M. R., Curry, S. & Matthews, S. Chemical shift mapping of RNA interactions with the polypyrimidine tract binding protein. Nucleic Acids Res. 30, 456-462 (2002). Abstract

Jacks, A., Kelly, G., Curry, S. & Conte, M. R. Resonance assignment and secondary structure determination of a C-terminal fragment of the lupus autoantigen (La) protein containing a putative RNA recognition motif (RRM). J. Biomol. NMR 22, 387-388 (2002). Pubmed

Simpson, P. J.,Davydova, N., Curry, S. & Matthews, S. Resonance assignment and topology of the 2H, 13C, 15N labelled 29 kDa N-terminal fragment of the polypyrimidine tract binding protein (PTB). J. Biomol. NMR 24, 79-80 (2002). Pubmed

Conte, M. R., Grüne, T., Ghuman, J., Kelly, G., Ladas, A., Matthews, S. & Curry, S. Structure of tandem RNA recognition motifs from polypyrimidine tract binding protein reveals novel features of the RRM fold. EMBO J. 19, 3132-3141 (2000). Abstract

Conte, M. R., Grüne, T., Curry, S. & Matthews, S. Resonance assignments and topology of a 22 kD C-terminal fragment of the polypyrimidine tract binding protein (PTB) containing two RNA binding domains. J. Biomol. NMR 14,383-384 (1999)

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Structural Virology: Viral Enzymes and Capsids (1992-date)

Zunszain, P.A., Knox, S.R., Sweeney, T.R., Yang, J., Roqué-Rosell, N., Belsham, G.J., Leatherbarrow, R.J & Curry, S. Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate J. Mol. Biol. 395, 375-389 (2010). Abstract | Open Access Reprint (inc. Supp. Info.) | Supp. Movie

Curry, S. Journal Club: A crystallographer takes a jaunt into immunology Nature 457, 133 (2009). Pubmed | Nature

Jaulent, A., Fahy, A., Knox, S.R., Birtley, J.R., Roqué-Rosell, N., Curry S. & Leatherbarrow, R.J. A continuous assay for foot-and-mouth disease virus 3C protease activity Anal. Biochem. 368, 130-137 (2007). Abstract

Sweeney, T.R., Roqué-Rosell, N., Birtley, J.R., Leatherbarrow, R.J. & Curry, S. Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the β-ribbon in proteolysis J. Virol. 81, 115-124 (2007). Abstract

Curry, S., Roqué-Rosell, N., Sweeney, T.R., Zunszain, P.A. & Leatherbarrow, R.J. Structural analysis of foot-and-mouth disease virus 3C protease: a viable target for antiviral drugs? Biochem. Soc. Trans. 35, 594-598 (2007). Abstract

Curry, S., Roqué-Rosell, N., Zunszain, P.A. & Leatherbarrow, R.J. Foot-and-mouth disease virus 3C protease: recent structural and functional insights into an antiviral target. Int. J. Biochem. Cell Biol. 39, 1-6 (2007). Abstract

Nayak, A., Goodfellow, I.G., Woolaway, K.E., Birtley, J.R., Curry S. & Belsham, G.J. Role of RNA structure and RNA binding activity of the foot-and-mouth disease virus 3C protein in VPg uridylylation and virus replication. J. Virol. 80, 9865-9875 (2006). Abstract

Fry, E.E., Newman, J.W.I., Curry, S. Najjam, S., Jackson, T., Blakemore, W., Lea, S.M., Miller, L., Burman, A., King, A.M.Q. & Stuart, D.I. Structure of foot-and-mouth disease virus serotype A10₆₁ alone and complexed with oligosaccharide receptor: receptor conservation in the face of antigenic variation. J. Gen. Virol. 86, 1909-1920 (2005). Abstract

Birtley, J.R. & Curry, S. Crystallization of foot-and-mouth disease virus 3C protease: surface mutagenesis and a novel crystal optimization strategy. Acta Cryst. D 61, 646-650 (2005). pdf | Abstract

Birtley, J.R., Knox, S.R., Jaulent, A.M., Brick, P., Leatherbarrow, R.J. & Curry, S. Crystal structure of foot-and-mouth disease virus 3C protease: new insights into mechanism and cleavage specificity. J. Biol. Chem. 280, 11520-11527 (2005). Abstract

Belnap, D. M. et al. Molecular tectonic model of virus structural transitions: the putative cell entry states of poliovirus. J. Virol. 74, 1342-1354 (2000). Abstract

van Vlijmen, H. W., Curry, S., Schaefer, M. & Karplus, M. Titration calculations of foot-and-mouth disease virus capsids and their stabilities as a function of pH. J. Mol. Biol. 275, 295-308 (1998). Abstract

Wien, M. W., Curry, S., Filman, D. J. & Hogle, J. M. Structural studies of poliovirus mutants that overcome receptor defects. Nature Struct. Biol. 4, 666-674 (1997). Abstract

Curry, S. et al. Dissecting the roles of VP0 cleavage and RNA packaging in picornavirus capsid stabilization: the structure of empty capsids of foot-and-mouth disease virus. J. Virol. 71, 9743-9752 (1997). Abstract

Curry, S., Chow, M. & Hogle, J. M. The poliovirus 135S particle is infectious. J. Virol. 70, 7125-7131 (1996). Abstract

Curry, S. et al. Perturbations in the surface structure of A22 Iraq foot-and-mouth disease virus accompanying coupled changes in host cell specificity and antigenicity. Structure 4, 135-145 (1996). Abstract

Lea, S. et al. Structural comparison of two strains of foot-and-mouth disease virus subtype O1 and a laboratory antigenic variant, G67. Structure 3, 571-580 (1995).   Abstract

Curry, S. et al. Viral RNA modulates the acid sensitivity of foot-and-mouth disease virus capsids. J. Virol. 69, 430-438 (1995). Abstract

Rowlands, D. et al. The structure of an immunodominant loop on foot and mouth disease virus, serotype O1, determined under reducing conditions. Arch. Virol. Suppl 9, 51-58 (1994). Abstract

Lea, S. et al. The structure and antigenicity of a type C foot-and-mouth disease virus. Structure 2, 123-139 (1994). Abstract

Logan, D. et al. Structure of a major immunogenic site on foot-and-mouth disease virus. Nature 362, 566-568 (1993). Abstract

Curry, S. et al. Crystallization and preliminary X-ray analysis of three serotypes of foot-and-mouth disease virus. J. Mol. Biol. 228, 1263-1268 (1992). Abstract

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HSA-ligand Interactions (1998-date)

Curry S. Lessons from the crystallographic analysis of small molecule binding to human serum albumin Drug Metab. Pharmacokinet. 24, 342-357 (2009).  Abstract & pdf

Nakagawa,A., Komatsu, T., Curry, S. and Tsuchida. E. The role of an amino acid triad at the entrance of the heme pocket in human serum albumin for O₂ and CO binding to iron protoporphyrin IX Org. Biomolec. Chem 7, 3836-3841 (2009).  Abstract

Nakagawa,A., Komatsu, T., Curry, S. and Tsuchida. E. O₂ Binding Properties of Human Serum Albumin Quadruple Mutant Complexed Iron Protoporphyrin IX with Axial His-186 Coordination Chem. Lett. 38, 776-777 (2009).  Abstract & pdf

Zunszain, P.A., Ghuman, J., McDonagh, A.F and Curry S. Crystallographic Analysis of Human Serum Albumin Complexed with 4Z,15E-Bilirubin-IXα J. Mol. Biol. 381, 394-406 (2008).  Abstract

Komatsu, T., Nakagawa, A., Zunszain, P.A., Curry, S. & Tsuchida, E. Genetic engineering of the heme pocket in human serum albumin: modulation of O₂ binding of iron protoporphyrin IX by variation of distal amino acids JACS 129, 11286-11295 (2007).  Abstract

Komatsu, T., Wang, R.-M., Zunszain, P.A., Curry, S. & Tsuchida, E. Photosensitized reduction of water to hydrogen using human serum albumin complexes with Zn-protoporphyrin IX. JACS 128, 16297-16301 (2006).  Abstract

Simard, J.R., Zunszain, P.A., Hamilton, J.A. & Curry, S. Location of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis. J. Mol. Biol. 361, 336-351 (2006).  Abstract

Fasano, M., Curry, S., Terreno, E., Galliano, M., Fanali, G., Narciso, P., Notari, S. & Ascenzi, P. The extraordinary ligand binding properties of human serum albumin. IUBMB Life 57, 787-796 (2005).  Abstract

Simard, J.R., Zunszain, P.A., Ha, C.-E., Yang, J., Bhagavan, N.V., Petitpas, I., Curry, S. & Hamilton, J.A. Locating high-affinity fatty acid binding sites on albumin by x-ray crystallography and NMR spectroscopy. Proc. Natl. Acad. Sci. USA 102, 17958-17963 (2005).  Abstract

Komatsu, T., Ohmichi, N., Nakagawa, A., Zunszain, P.A., Curry, S. & Tsuchida, E. O₂ and CO binding properties of artificial hemoproteins formed by complexing iron protoporphyrin IX with human serum albumin mutants. JACS 127, 15933-15942 (2005).  Abstract

Ghuman, J. Zunszain, P.A., Petitpas, I., Bhattacharya, A.A., Otagiri, M. & Curry, S. Structural basis of the drug-binding specificity of human serum albumin. J. Mol. Biol. 353, 38-52 (2005).  Abstract

Komatsu, T., Ohmichi, N., Zunszain, P.A., Curry, S. & Tsuchida, E. Dioxygenation of human serum albumin having a prosthetic heme group in a tailor-made heme pocket. JACS 126, 14304-14305 (2004).  Abstract

Curry, S. Lipobiology (Ch. 3): Plasma albumin as a fatty acid carrier. Adv. Mol. Cell. Biol. 33, 29-46 (2004).  Book Publisher

Zunszain, P.A., Ghuman, J., Komatsu, T., Tsuchida, E. & Curry, S. Crystal structural analysis of human serum albumin complexed with hemin and fatty acid. BMC Structural Biology 3:6 (2003).  Open Access Paper

Petitpas, I., Petersen, C. E., Ha, C. E., Bhattacharya, A. A., Zunszain, P. A., Ghuman, J., Bhagavan, N. V. & Curry, S. Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia. Proc. Natl. Acad. Sci. USA 100, 6440-6445 (2003).  Abstract

Petersen, C. E., Ha, C. E., Curry, S. & Bhagavan, N. V. Probing the structure of the warfarin-binding site on human serum albumin using site-directed mutagenesis. Proteins 47, 116-125 (2002). Abstract

Curry, S. Beyond expansion: structural studies on the transport roles of human serum albumin. Vox Sang. 83 Suppl 1, 315-319 (2002). Pubmed

Choi, J. K., Ho, J., Curry, S., Qin, D., Bittman, R. & Hamilton, J. A. Interactions of very long-chain saturated fatty acids with serum albumin. J. Lipid Res. 43, 1000-1010 (2002). Abstract

Petitpas, I., Grüne, T., Bhattacharya, A. A. & Curry, S. Crystal structures of human serum albumin complexed with monounsaturated and polyunsaturated fatty acids. J. Mol. Biol. 314, 955-960 (2001). Abstract

Petitpas, I., Bhattacharya, A. A., Twine, S., East, M. & Curry, S. Crystal structure analysis of warfarin binding to human serum albumin: anatomy of drug site I. J. Biol. Chem. 276, 22804-22809 (2001). Abstract

Bhattacharya, A. A., Grüne, T. & Curry, S. Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin. J. Mol. Biol. 303, 721-732 (2000). Abstract

Bhattacharya, A. A., Curry, S. & Franks, N. P. Binding of the general anesthetics propofol and halothane to human serum albumin. High resolution crystal structures. J. Biol. Chem. 275, 38731-38738 (2000). Abstract

Curry, S., Brick, P. & Franks, N. P. Fatty acid binding to human serum albumin: new insights from crystallographic studies. Biochim. Biophys. Acta 1441, 131-140 (1999). Abstract

Curry, S., Mandelkow, H., Brick, P. & Franks, N. Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites. Nature Struct. Biol. 5, 827-835 (1998). Abstract | News & Views

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General Anaesthetics Research (PhD)

Moss, G. W., Curry, S., Franks, N. P. & Lieb, W. R. Mapping the polarity profiles of general anesthetic target sites using n-alkane-(alpha,omega)-diols. Biochemistry 30, 10551-10557 (1991). Abstract

Curry, S., Moss, G. W., Dickinson, R., Lieb, W. R. & Franks, N. P. Probing the molecular dimensions of general anaesthetic target sites in tadpoles (Xenopus laevis) and model systems using cycloalcohols. Br. J. Pharmacol. 102, 167-173 (1991). Abstract

Curry, S., Lieb, W. R. & Franks, N. P. Effects of general anesthetics on the bacterial luciferase enzyme from Vibrio harveyi: an anesthetic target site with differential sensitivity.Biochemistry 29, 4641-4652 (1990). Abstract

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8 Jan 2010
http://www.bio.ph.ic.ac.uk/~scurry/