|The Anaesthesia and Neuronal Excitability Group
in Biophysics uses a multidisciplinary approach to study ion channel function in the CNS. We share recently refurbished laboratories and have closely overlapping interests.
Principal Investigators and Research Interests
The research undertaken in the Anaesthesia and Neuronal Excitability Group can be divided
into four main areas:
|Ion channel structure and function
||We are interested in the interactions that occur
between synaptic receptors and their specific ligands and modulators.
|Mechanisms of anaesthetic action
||We are studying the effects of general anaesthetics
on specific receptors in the brain.
|Control of sleep wake states
||We are exploring the possibility that anaesthetics act on the same receptors that
are responsible for regulating our sleep wake patterns.
|Regulation of brain metabolism
||We are examining the role of the vagal system in the control
of energy metabolism, in order to develop effective cures for metabolic disorders.
|For more details on
the different research programs, refer to the individual home pages
of each P.I.
The Anaesthesia and Neuronal Excitability Group employs a variety
of functional assays to study molecular and cellular mechanisms of brain function.
The techniques routinely used within the group include: whole-cell recording,
electroencephalogram (EEG) & extracellular spike detection, recombinant
expression techniques, site-directed mutagenesis, single cell PCR, in situ hybridization,
immumohistochemistry, chromatography & mass spectrometry, light and confocal microscopy.
We welcome approaches from prospective graduate students and postdocs
(see PG opportunities page)
or from potential collaborators.
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