Imperial College Centre for Structural Biology   Protein Crystallography Course for Postdocs and PhD students (2011) The course is designed for postdocs and graduate students who are currently engaged in crystallographic projects but who may not have had any formal training in the theory and practice of macromolecular crystallography. It is now also offered as part of the MRes in Structural Biology which is run by the Imperial College Centre for Structural Biology. Students on the MRes in Biochemical Research who have a strong interest in crystallography are also welcome to attend. There will be a total of twelve 2 hour lectures which will be given at 10:30 am in Huxley 747 on Mondays, Wednesdays and Fridays. A timetable (with downloadable handouts) is available. Make sure to grab these before each lecture. Course lecturers (@imperial.ac.uk) are: Peter Brick (p.brick) Stephen Curry (s.curry) Erhard Hohenester (e.hohenester)

The topics to be covered are listed in brief below. A more detailed syllabus is also available.  1  Basic diffraction theory Stephen  2  Crystallisation of macromolecules Erhard  3  Crystal symmetry Erhard  4  X-ray data collection Peter  5  Phasing methods I: Isomorphous replacement Peter  6  Phasing methods II: Molecular replacement Erhard  7  Phasing methods III: Multiple anomalous dispersion Peter  8  Non-crystallographic symmetry and density modification Erhard  9  Protein structure/model building Stephen  10  Refinement Stephen

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